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These populations should avoid peptide therapy until more data is available

Functional sepiapterin reductase is a homodimeric enzyme which first converts 6-pyruvoyltetrahydropterin to 1-hydroxy-2-oxopropyltetrahydropterin, which is then reduced to 1-oxo-2-hydroxypropyltetrahydropterin, and then finally to 5,6,7,8-tetrahydrobiopterin, BH 4

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Published work links its activity to nitric-oxide pathway signaling, FAK-paxillin cell-adhesion pathways, growth-factor receptor expression, and dopaminergic and serotonergic systems

If initial daily administration has been maintained for more than 2 weeks, extending this washout to 57 days allows fuller recovery from any receptor downregulation that may have occurred